Regeneration of Peritoneal Mesothelium in a Rat Model of Peritoneal Fibrosis

A microrna screen to identify regulators of peritoneal fibrosis in a rat model of peritoneal dialysis

BACKGROUND Peritoneal fibrosis is a common complication in patients treated with long-term peritoneal dialysis. The aim of this study was to identify the microRNAs (miRNAs) involved in regulation of peritoneal fibrosis in a rat model of peritoneal dialysis. METHODS Twenty-four Sprague-Dawley (SD) rats were randomly allocated into three groups: (i) Control group (Cg, n = 8); (ii) Saline group ...

Angiogenic Activity of the Peritoneal Mesothelium: Implications for Peritoneal Dialysis

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model.

BACKGROUND Atrial natriuretic peptide (ANP) was recently reported to ameliorate fibrosis in the heart and experimental renal diseases and vascular thickening after balloon injury. Peritoneal fibrosis is an important complication of long-term peritoneal dialysis, and peritonitis is a factor in its onset. In the present study, we investigated the effects of ANP in a rat peritonitis-induced perito...

Treatment of established peritoneal fibrosis by gene transfer of Smad7 in a rat model of peritoneal dialysis.

BACKGROUND/AIMS It has been shown that blockade of TGF-beta1 signaling with Smad7 prevents experimental peritoneal fibrosis. The present study investigated whether Smad7 has a therapeutic effect on established peritoneal fibrosis associated with peritoneal dialysis (PD). METHODS A rat model of peritoneal fibrosis was induced by a daily intraperitoneal infusion of 4.25% Dianeal. After peritone...

Organization of cell junctions in the peritoneal mesothelium

Intercellular junctions in the mesothelium of the visceral (mesentery and omentum), and parietal (diaphragm, pre-aortic, and iliac region) peritoneum were examined in rats and mice by using freeze-cleaved preparations. In addition to usual intercellular junctions (cell body junctions), special junctions are found between cell processes and the surface of the neighboring cell (cell process junct...